GLP-1 for Weight Loss in South Africa: What You Need to Know
- Dr Ben Coetsee
- Feb 21
- 4 min read
Updated: 3 days ago
Weight management is a challenge for many South Africans, and with the rise in obesity-related health issues, GLP-1 medications like Ozempic (semaglutide) have gained significant attention. While originally developed for managing type 2 diabetes, Ozempic has become a popular option for weight loss due to its ability to regulate appetite and slow digestion.

South Africans considering GLP-1 for weight loss often wonder: how quickly does it work, what results can be expected, and how accessible is it locally? In this guide, we explore the timeline for weight loss, factors affecting its effectiveness, and how to make the most of Ozempic as part of a sustainable lifestyle change.
How Does GLP-1 Work for Weight Loss?
Ozempic contains semaglutide, a GLP-1 receptor agonist that mimics a natural hormone in the body responsible for regulating blood sugar and appetite. By slowing gastric emptying and increasing the feeling of fullness, Ozempic helps individuals consume fewer calories, leading to gradual and sustainable weight loss.
Unlike traditional weight loss methods, which rely on diet and exercise alone, GLP-1 enhances weight loss efforts by reducing cravings and improving portion control. However, for optimal results, it should be combined with healthy eating habits and regular physical activity.
How Quickly Can You Lose Weight on GLP1?
While results vary from person to person, clinical trials suggest that individuals using GLP-1 for weight loss can expect to see initial changes within the first four weeks.
However, significant weight reduction often takes several months. On average:
First Month: A modest weight loss of 1-2 kg as the body adjusts.
Three Months: A 5-6% reduction in total body weight.
Six Months: Users may experience up to 10% weight loss, depending on lifestyle factors.
One Year and Beyond: Some individuals report a 15% or greater reduction in body weight with continued use and adherence to a healthy lifestyle.
It’s important to note that results depend on factors like diet, exercise, and individual metabolic responses. South Africans using GLP-1 medications should track their progress and consult with their healthcare providers for personalized guidance.
Accessibility and Availability of GLP-1 in South Africa

GLP-1 medications are available in South Africa primarily through private healthcare providers and select pharmacies. Given its growing popularity for weight loss, demand for the medication has increased, occasionally leading to shortages. Individuals interested in starting GLP-1 medications should consult with their doctors to obtain a prescription and confirm availability at their preferred pharmacy.
Where to Find GLP-1 medications in South Africa:
Private medical practices and endocrinologists
Pharmacies such as Dis-Chem and Clicks
Online pharmaceutical retailers with valid prescriptions
Medical weight management programs
Due to its cost, GLP-1 medications may not always be covered by medical aids unless prescribed for diabetes treatment. Patients should check with their healthcare providers and insurance companies to understand their options.
Factors Influencing Weight Loss Speed

Weight loss with GLP-1 medications is not a one-size-fits-all process. Several factors impact how quickly South African users may see results:
Dosage Adjustments: Starting at 0.25 mg per week and gradually increasing to 1.0 mg or higher enhances effectiveness.
Dietary Habits: A balanced, nutrient-rich diet enhances weight loss and prevents nutrient deficiencies.
Physical Activity: Regular exercise improves metabolism and supports long-term results.
Metabolic Rate: Individual differences in metabolism affect how quickly weight loss occurs.
Adherence to Treatment: Consistency with medication and lifestyle changes is key.
Managing Expectations and Overcoming Plateaus
South African users of GLP-1 medications should set realistic goals and understand that weight loss is a gradual process. Some may experience plateaus where progress slows. To overcome this, individuals can:
Increase physical activity levels
Adjust calorie intake based on progress
Monitor portion sizes and eating patterns
Stay hydrated and ensure adequate sleep
Consult with a healthcare provider for adjustments
Long-term success with Ozempic requires patience and commitment to sustainable lifestyle changes.
Common Side Effects and Safety Considerations
While GLP-1 medications is generally well-tolerated, some users may experience side effects, including:
Nausea
Stomach cramps
Constipation or diarrhea
Fatigue
Dizziness
Most side effects subside as the body adjusts to the medication. However, individuals should seek medical advice if symptoms persist or worsen.
In South Africa, healthcare professionals emphasize the importance of using Ozempic under medical supervision. It is not a quick-fix solution but rather a tool to support a healthier lifestyle.
Long-Term Use and Maintaining Weight Loss
Stopping GLP-1 medications without maintaining lifestyle changes may result in weight regain. To sustain results, South African users should focus on:
Continuing a healthy diet
Engaging in regular exercise
Practicing mindful eating
Seeking ongoing support from healthcare professionals
By integrating these habits into daily life, individuals can achieve lasting success beyond medication use.
Conclusion
GLP-1 medications have become a valuable option for weight loss in South Africa, offering gradual and sustainable results when used correctly. While timelines for noticeable weight reduction vary, combining GLP-1 medications with a balanced diet and active lifestyle significantly improves outcomes.
For South Africans considering GLP-1 medications, consulting a healthcare provider, understanding accessibility, and setting realistic goals are crucial steps. With the right approach, GLP-1 medications can be an effective tool in achieving and maintaining a healthier weight.
Would you like further insights on meal planning or exercise tips to complement your GLP-1 medications journey? Book a Session with Performance MD Today.
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